DIABETIC CARDIAC AUTONOMIC NEUROPATHY: EFFECT OF BENFOTIAMINE ON THE CORRECTED QT INTERVAL, QT DISPERSION AND SPATIAL QRS-T ANGLE

The significance of cardiac autonomic neuropathy (CAN) has not been fully appreciated and there is no unified treatment algorithm. Aim: To investigate the effects benfotiamine (BFT) on corrected QT interval (QTc), dispersion (QTd) spatial QRS-T angle in patients with type 2 diabetes mellitus (T2DM) CAN. 32 T2DM definite stage CAN were allocated to two groups: control (n = 15) received standard antihyperglycemic therapy; group 17) - addition BFT 300 mg/d for three months. QTc interval, QTd parameters analyzed. It was found out that contributed decrease QTc, angle. positive influences suggests feasibility its administration Obtained results suggest efficacy result a direct effect investigated indexes.